Tirthraj Adhikari

Molecular Imaging
600+ km trek across the Himalayas for cancer therapy
It takes on average 18 hours by bus for patients to reach the cancer hospital in Nepal, and many of them travel over 600 km. Now the pandemic has made it even more difficult to get treatment, writes Tirthraj Adhikari, a medical physicist trained in Italy. He gives a personal account of the challenges faced by patients and staff.
September 22, 2020
2020 09 23 15 29 5985 Nepal Village 400
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Example case from test set with biparametric MRI data, reference segmentation, and output from AI system. The primary MRI assessment resulted in a PI-RADS 5 lesion in the left dorsal part of the peripheral zone and a PI-RADS 4 lesion in the right dorsal part of the peripheral zone (PSA of 11.6 μg/L). Targeted biopsies from both areas showed ISUP-grade 3. All images are from the same slice location, showing a part of both lesions. A T2-weighted (T2W) image. B Diffusion-weighted image with a b-value of 1,500 s/mm2. (C) Apparent diffusion coefficient map. (D) Reference segmentation with white areas representing tumor. (E) Softmax output from AI system. Inset in the lower left corner shows the detection map (cropped around the prostate) with red voxels representing softmax values of 0.99 and yellow voxels representing softmax values of 0.59. (F) T2W image with reference (D) and detection map (inset in E) overlayed, green represents areas in which both the reference and the AI output are positive (true positive voxels for AI), red only positive in reference (false-negative voxels for AI) and blue only segmented by AI (false-positive voxels for AI).
MRI
AI comes under scrutiny in Swedish prostate MRI study
An AI system trained in a screening population has lower specificity than radiologists using PI-RADS v2, but considerable care is vital, researchers from Gothenburg reported in European Radiology on 8 December.
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Molecular Imaging
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Nuclear Medicine
PET/MRI detects ‘unknown’ generators of musculoskeletal pain
Postoperative 3D volume rendering of the fenestrated endograft reconstruction: 3D volume-rendered reconstruction obtained in Horos using the standard soft-tissue preset. The image displays the postoperative appearance of the fenestrated endograft and visceral stents, extending from the descending thoracic aorta to the iliac bifurcation, acquired during the follow-up CT angiogram one month after the procedure. The reconstruction shows patent visceral branches with well-perfused stents, absence of endoleak, and successful restoration of the previously disconnected left limb with adequate iliac perfusion.
3D Printing
Digital workflows, 3D models enhance preoperative planning
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AI comes under scrutiny in Swedish prostate MRI study
By Philip Ward
An AI system trained in a screening population has lower specificity than radiologists using PI-RADS v2, but considerable care is vital, researchers from Gothenburg reported in European Radiology on 8 December.
December 9, 2025
Example case from test set with biparametric MRI data, reference segmentation, and output from AI system. The primary MRI assessment resulted in a PI-RADS 5 lesion in the left dorsal part of the peripheral zone and a PI-RADS 4 lesion in the right dorsal part of the peripheral zone (PSA of 11.6 μg/L). Targeted biopsies from both areas showed ISUP-grade 3. All images are from the same slice location, showing a part of both lesions. A T2-weighted (T2W) image. B Diffusion-weighted image with a b-value of 1,500 s/mm2. (C) Apparent diffusion coefficient map. (D) Reference segmentation with white areas representing tumor. (E) Softmax output from AI system. Inset in the lower left corner shows the detection map (cropped around the prostate) with red voxels representing softmax values of 0.99 and yellow voxels representing softmax values of 0.59. (F) T2W image with reference (D) and detection map (inset in E) overlayed, green represents areas in which both the reference and the AI output are positive (true positive voxels for AI), red only positive in reference (false-negative voxels for AI) and blue only segmented by AI (false-positive voxels for AI).
Molecular imaging can trigger next revolution in radiology
By Amerigo Allegretto
Molecular imaging will play a key role in precision medicine, and radiology will be at the forefront in ensuring the best patient outcomes, predicts RSNA President Dr. Umar Mahmood, PhD.
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Challenging inequity: ESR group spells out why it matters
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Radiology staff must recognize how inequities in imaging affect patients from minority groups, says the ESR subcommittee on equity, diversity, and inclusivity.
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PET/MRI detects ‘unknown’ generators of musculoskeletal pain
By Will Morton
Potential pain generators were identified by increased F-18 FDG radiotracer uptake on PET and/or structural abnormalities on MRI.
December 5, 2025
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Digital workflows, 3D models enhance preoperative planning
By Maryam Payne
Low-cost digital workflows using 3D printing and AI-assisted model-building can prove valuable for preoperative planning.
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Postoperative 3D volume rendering of the fenestrated endograft reconstruction: 3D volume-rendered reconstruction obtained in Horos using the standard soft-tissue preset. The image displays the postoperative appearance of the fenestrated endograft and visceral stents, extending from the descending thoracic aorta to the iliac bifurcation, acquired during the follow-up CT angiogram one month after the procedure. The reconstruction shows patent visceral branches with well-perfused stents, absence of endoleak, and successful restoration of the previously disconnected left limb with adequate iliac perfusion.
Cryoablation treats early-stage breast cancer in older women
By Amerigo Allegretto
Cryoablation is effective in treating early-stage breast cancer in older women who do not undergo surgery, a team from Madrid reported at RSNA 2025.
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Rsna 2025 Welcome
3D-printed prostheses bring hope in conflict zones
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3D-printing allows for faster, lighter, more affordable, and highly customized prosthetic production, and the technology can help patients regain mobility.
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A smartphone is used to take an image for a 3D-printed prosthesis.
Stent procedure proves safe in pediatric liver transplant cases
By Will Morton
Biodegradable stents appear safe and effective for treating narrowing of the bile ducts in children after liver transplants, Italian researchers noted at RSNA 2025.
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Biliary Atresia Disease Adobe Pikovit
Radiology must persevere with sustainability efforts
By Kate Madden Yee
It's crucial to reduce medical imaging's energy use and waste to mitigate the effect of global warming, warns RSNA 2025 keynote speaker Dr. Geraldine McGinty.
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Sustainability Image
GE HealthCare features new MRI scanners, PCCT system
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Two new MRI scanners and a photon-counting CT (PCCT) system are among the RSNA 2025 highlights for GE HealthCare.
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Abdominal obesity linked to heart damage
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Abdominal obesity appears to lead to a potentially pathological form of cardiac remodeling called concentric hypertrophy, German researchers have asserted.
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France gets set to shine at RSNA 2025
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An abundance of Gallic charm and research excellence promise to light up McCormick Place in Chicago on Tuesday.
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Patient with diffuse myocardial edema. Myocardial late gadolinium enhancement shows myocarditis caused by immune checkpoint inhibitors. Courtesy of Prof. Alexis Jacquier.
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