2nd BIR Masterclass: Prostate cancer theragnostics

Nov 9th, 2023
H9
GB
https://www.mybir.org.uk/l/s/community-event?id=a173Y00000GQSatQAH
Phone:+44 (0)20 3668 2228
National and International faculty aim to share their experience and discuss practical issues related to diagnostic and therapeutic applications, with a focus on PSMA and PSMA PET-CT.
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Example case from test set with biparametric MRI data, reference segmentation, and output from AI system. The primary MRI assessment resulted in a PI-RADS 5 lesion in the left dorsal part of the peripheral zone and a PI-RADS 4 lesion in the right dorsal part of the peripheral zone (PSA of 11.6 μg/L). Targeted biopsies from both areas showed ISUP-grade 3. All images are from the same slice location, showing a part of both lesions. A T2-weighted (T2W) image. B Diffusion-weighted image with a b-value of 1,500 s/mm2. (C) Apparent diffusion coefficient map. (D) Reference segmentation with white areas representing tumor. (E) Softmax output from AI system. Inset in the lower left corner shows the detection map (cropped around the prostate) with red voxels representing softmax values of 0.99 and yellow voxels representing softmax values of 0.59. (F) T2W image with reference (D) and detection map (inset in E) overlayed, green represents areas in which both the reference and the AI output are positive (true positive voxels for AI), red only positive in reference (false-negative voxels for AI) and blue only segmented by AI (false-positive voxels for AI).
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