Prof. Paul Sidhu

Ultrasound
Why it pays off to know about contrast-enhanced ultrasound
Contrast-enhanced ultrasound is now an indispensable point-of-care or problem-solving tool, answering a clinical conundrum in minutes, if not seconds, says Prof. Paul Sidhu.
May 12, 2025
In a 47-year-old man with upper abdominal pain, ultrasound shows a fatty liver and an atypical lesion (arrow). The CEUS examination answered the question in 30 seconds -- this is a hemangioma, with classical pathognomonic peripheral globular enhancement (arrow). It’s a “slam-dunk” diagnosis: no further imaging, no further costs, and the patient knows immediately that this is benign. Figure courtesy of Prof. Paul Sidhu.
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Example case from test set with biparametric MRI data, reference segmentation, and output from AI system. The primary MRI assessment resulted in a PI-RADS 5 lesion in the left dorsal part of the peripheral zone and a PI-RADS 4 lesion in the right dorsal part of the peripheral zone (PSA of 11.6 μg/L). Targeted biopsies from both areas showed ISUP-grade 3. All images are from the same slice location, showing a part of both lesions. A T2-weighted (T2W) image. B Diffusion-weighted image with a b-value of 1,500 s/mm2. (C) Apparent diffusion coefficient map. (D) Reference segmentation with white areas representing tumor. (E) Softmax output from AI system. Inset in the lower left corner shows the detection map (cropped around the prostate) with red voxels representing softmax values of 0.99 and yellow voxels representing softmax values of 0.59. (F) T2W image with reference (D) and detection map (inset in E) overlayed, green represents areas in which both the reference and the AI output are positive (true positive voxels for AI), red only positive in reference (false-negative voxels for AI) and blue only segmented by AI (false-positive voxels for AI).
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Week in Review: New data on radiation dose | Junior doctors and CT | GI complications from raw fish
By Philip Ward
Spanish-led research suggests that more work needs to be done to manage radiation dose in children, adolescents, and young adults. Click "Read More" for the details of this story as well as a roundup of our top stories of the week.
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